Gatekeeper reflux repair system; a mechanistic hypothesis
نویسندگان
چکیده
منابع مشابه
Gatekeeper reflux repair system; a mechanistic hypothesis.
A lthough there can clearly be an argument regarding the threshold at which it becomes a disease, gastro-oesophageal reflux disease (GORD) is ultimately the result of excessive gastro-oesophageal reflux and the associated consequences of that. It then seems rather straightforward that therapeutic interventions should seek to reduce or eliminate gastrooesophageal reflux. The paradox is that the ...
متن کاملEffect of endoscopic augmentation of the lower oesophageal sphincter (Gatekeeper reflux repair system) on intraoesophageal dynamic characteristics of acid reflux.
BACKGROUND AND AIMS Improvements in symptoms following endoscopic procedures for gastro-oesophageal reflux disease (GORD) are seldom supported by normalisation of acid exposure time at the distal oesophagus. However, the distribution of gastric acid within the proximal oesophagus is a main determinant of symptom generation in GORD patients. In this study, our aim was to assess the effect of end...
متن کاملGASTRO-OESOPHAGEAL REFLUX Effect of endoscopic augmentation of the lower oesophageal sphincter (Gatekeeper reflux repair system) on intraoesophageal dynamic characteristics of acid reflux
Background and aims: Improvements in symptoms following endoscopic procedures for gastrooesophageal reflux disease (GORD) are seldom supported by normalisation of acid exposure time at the distal oesophagus. However, the distribution of gastric acid within the proximal oesophagus is a main determinant of symptom generation in GORD patients. In this study, our aim was to assess the effect of end...
متن کاملA Mechanistic Hypothesis to Explain the Timing Hypothesis
The timing hypothesis posits that exogenous estrogen plus progestin (E+P) hormone therapy (HT) is generally beneficial when initiated in proximity to the final menstrual period, but this benefit decreases and can lead to increased risk when initiated six to ten years later. This concept has been put forward to explain the discrepancies across randomized clinical trials assessing HT for preventi...
متن کاملMechanistic insights into transcription coupled DNA repair.
Transcription-coupled DNA repair (TCR) acts on lesions in the transcribed strand of active genes. Helix distorting adducts and other forms of DNA damage often interfere with the progression of the transcription apparatus. Prolonged stalling of RNA polymerase can promote genome instability and also induce cell cycle arrest and apoptosis. These generally unfavorable events are counteracted by RNA...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Gut
سال: 2005
ISSN: 0017-5749
DOI: 10.1136/gut.2004.051805